If a nursing mom is an extremely-speedy metabolizer of codeine, it could lead on to morphine overdose in the nursing toddler and bring about extremely severe Unwanted effects.
Postmarketing situations of respiratory melancholy, like fatalities, have already been claimed with usage of promethazine in pediatric people. Concomitant administration with other respiratory depressants may enhance the risk of respiratory despair.
A most likely lethal symptom complicated occasionally generally known as Neuroleptic Malignant Syndrome (NMS) continues to be documented in Affiliation with promethazine HCl by itself or in combination with antipsychotic medicine.
A house teaspoon just isn't an precise measuring machine and could lead to overdosage. For prescriptions where a measuring system just isn't delivered, a pharmacist can provide an appropriate measuring machine and can provide Recommendations for measuring the correct dose. Don't overfill. Rinse the measuring gadget with h2o after Every single use.
This medicine may very well be behavior-forming. In the event you feel that the medication is not really Functioning likewise, do not use over your prescribed dose. Contact your doctor for Directions.
Speak to your pharmacist or contact your local garbage/recycling Division to find out about acquire-back again programs with your Local community. Begin to see the FDA's Safe Disposal of Medicines Web page () To find out more if you do not have usage of a just take-back again plan.
To reduce the chance of dizziness and lightheadedness, stand up slowly but surely when mounting from a sitting or lying position.
Unneeded medications should be disposed of in Particular strategies in order that pets, small children, and other people are not able to consume them. Nonetheless, you should not flush this medication down the rest room. In its place, The easiest way to dispose of your medication is thru a drugs get-again plan.
Promethazine comes for a tablet and syrup (liquid) to just take by mouth and as being a suppository to make use of rectally.When promethazine is applied to treat allergy symptoms, it is often taken 1 to 4 situations day-to-day, before foods and/or at bedtime. When promethazine is used To ease chilly signs and symptoms, it is usually taken each four to six several hours as needed. When promethazine is utilized to treat motion sickness, it is taken thirty to sixty minutes prior to journey and once more soon after 8 to twelve several hours if essential. On extended journeys, promethazine will likely be taken in the morning and ahead of the evening food on every day of travel.
Small children Postmarketing instances of respiratory melancholy, like fatalities, are actually described with use of promethazine in pediatric individuals. Concomitant administration with other respiratory depressants may possibly increase the danger of respiratory depression.
Liver sickness—Use with caution. The consequences could possibly be increased on account of slower removing of your medicine from your body.
strategy in order to avoid needless or prolonged publicity to daylight and Promethazine codeine syrup also to put on protecting clothes, sun shades, and sunscreen. Promethazine could make your skin sensitive to sunlight.
Promethazine may well result in respiratory to sluggish or stop, and may lead to Dying in youngsters. Promethazine really should not be presented to infants or small children who're more youthful than 2 many years aged and may be presented with caution to kids who are 2 yrs of age or more mature. Mixture products that contains promethazine and codeine shouldn't be offered to young children young than 16 many years aged. Promethazine must not routinely be made use of to treat vomiting in small children; it ought to only be Employed in distinct cases when a health care provider decides that it is needed.
Critical, daily life-threatening, or lethal respiratory depression has become described with the usage of opioids, including codeine, among the list of Energetic substances in Promethazine with Codeine Oral Alternative. Codeine creates dose-connected respiratory melancholy by instantly acting to the Mind stem respiratory Heart that controls respiratory rhythm and will make irregular and periodic respiration. Codeine is topic to variability in metabolism based upon CYP2D6 genotype, which can lead to an elevated publicity for the Lively metabolite morphine [see WARNINGS AND Safeguards (five.three)]. Promethazine exerts a depressant effect on the respiratory Middle which is independent of and additive to that of other respiratory depressants, including codeine [see WARNINGS AND PRECAUTIONS (5.